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Current Projects

Project Title Breast Cancer Risk in Young Women Study

Researcher Paul Goodfellow, PhD, The Ohio State University College of Medicine, Columbus, OH, and Jennifer Ivanovich, MS, Washington University School of Medicine, St. Louis, MO

Study Summary The purpose of the study is to learn what genetic factors may play a role in the development of breast cancer in young women. The researchers need to recruit 5,000 women who were diagnosed with invasive breast cancer when they were 40 years old or younger for this study.

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Project Title Breast Cancer Microbiota Study

Researcher Ece Mutlu, MD, Rush University Medical Center, Chicago, Illinois

Study Summary The purpose of this study is to find out what types of bacteria are found in the intestines and how these bacteria metabolize estrogen and other female hormones. The researchers are comparing the bacteria found in women who have never had breast cancer, women who have been diagnosed with breast cancer within the last 5 years, and women who have never had breast cancer but who have a first-degree relative WITH breast cancer.

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Project Title Genomic Analysis of Breast Cancer Risk

Researcher Harry Ostrer, MD, Albert Einstein College of Medicine, Bronx, New York

Study Summary The purpose of this study is to identify new genetic mutations for breast cancer. The research team will analyze blood samples from two groups of survivors: women with a strong family history of breast and/or ovarian cancer and women who had early onset breast cancer but no family history. All study participants must have been tested for— and found not to have—the BRCA1 and BRCA2 genetic mutations.

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Project Title Genomics and Breast Cancer Risk in Hispanic Women Study

Researcher Susan Neuhausen, PhD, City of Hope, Duarte, CA

Study Summary The goal of this study is to learn more about breast cancer in Hispanic women by studying Hispanic women with breast cancer and Hispanic women who have never had breast cancer. The research team has enrolled Hispanic women with breast cancer for the study. Now, they need Hispanic women who have never had any type of cancer (skin cancers are okay). If you enroll in this study, you will NOT receive any individual genetic test results. Every participant is assigned a coded study number, and no genetic information is connected to her name. There is no way for the researchers to ever tell you anything about your test results. By taking part in this study, you will help researchers help future generations of Hispanic Women.

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Project Title A Pilot Study of the Flaxseed Effects on Hormones and Lignans: Role of Race, Genes, and Gut Microbiome

Researcher Susan McCann, PhD, Roswell Park Cancer Institute

Study Summary The purpose of this study is to determine whether adding flaxseed (a food high in compounds that can change hormones) to a regular diet changes hormones that are related to breast cancer risk and if the effect of flaxseed differs between African- American and Caucasian women.

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Project Title Acupuncture for Joint Symptoms in Women with Early Stage Breast Cancer

Researcher Southwest Oncology Group, (SWOG)

Study Summary The purpose of this study is to test whether 12-weeks of acupuncture can help reduce joint pain or stiffness caused by hormonal therapy for breast cancer. The researchers need to enroll 228 women in this study.

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Project Title A Study to Identify Predictors of Response to Duloxetine in Breast Cancer Patients with Chronic Pain (HUM00075181)

Researcher Norah Henry, University of Michigan, MD, PhD

Study Summary The purpose of this study is to better understand why some breast cancer survivors who have chronic pain and are treated with duloxetine will have their level of pain improve, while others will not. Women with breast cancer who have chronic pain will be asked to enroll. Participants will be treated with duloxetine for 7 weeks in order to determine how the medication affects both their level of pain and their sensitivity to pain. The research team hopes to understand more about why breast cancer survivors develop pain after their diagnosis and treatment, and why some people respond better to this type of treatment. The research team needs 84 women to participate in this study.

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Project Title A Phase II Study of Neratinib in Metastatic HER2 Non-amplified but HER2 Mutant Breast Cancer

Researcher Cynthia Ma, M.D., Ph.D., Washington University, St Louis, MO

Study Summary The purpose of this study is to see whether neratinib is effective in treating HER2-negative metastatic tumors that have this specific HER2 mutation. The first part of the study is a preliminary screening. During this part of the study, your tumor tissue will be tested to see if it has the HER2 mutation the researchers are looking for. If your tumor has the mutation, you will be given more information about the main research study, which is investigating the effectiveness of neratinib.

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Project Title Feasibility Study: Breast Tissue Effects of Hormonal Contraceptive Formulations Study

Researcher Anne Zeleniuch-Jacquotte, MD, MS, and Tess Clendenen, PhD, New York University Medical Center, NY

Study Summary The purpose of this study is to find out if there are enough women in the New York Metro Area (including New York City, Long Island, New Jersey, and Connecticut) who would be eligible and potentially interested in participating in a future study that would require them to go to NYU Medical Center for a breast MRI, and a breast biopsy and collection of a small blood sample. Information obtained from the anonymous, online questionnaire would be used to plan a future study investigating the effects of different hormonal birth control formulations on breast tissue. Right now, the research team needs women who have used ANY type of hormonal birth control now or in the past to complete an anonymous, online questionnaire about their health and reproductive history.

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Project Title Multimodal MRI Biomarkers of Mild Cognitive Impairment in Breast Cancer

Researcher Shelli Kesler, PhD, University of Texas MD Anderson Cancer Center, Houston, Texas

Study Summary The goal of this research study is to learn about brain activity that may be related to changes in brain function in women with breast cancer. The research team also wants to learn about brain activity that could be used to predict which women may be more likely to develop these changes. They need information from healthy women to help determine what “normal” brain function looks like so they can compare this to information from women with breast cancer.

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Project Title Genetics of Chemotherapy-Related Amenorrhea Study

Researcher Kathryn Ruddy, MD MPH, and Celine Vachon, PhD, Mayo Clinic, Rochester, Minnesota

Study Summary The purpose of this study is to learn whether there are certain genes that contribute to the effect that chemotherapy has on a woman’s ovaries. The research team needs 5,000 women who were diagnosed with breast cancer and treated with chemotherapy before age 50 to participate in this study.

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Project Title Avon Viral IL-10 in Cancer Study (AVICS)

Researcher Juliet Spencer, PhD, University of San Francisco, CA

Study Summary This study will allow researchers to evaluate cmIL-10 blood levels in breast cancer patients and compare cmIL-10 levels in healthy women and women diagnosed with breast cancer within the last 5 years. If the study finds that some breast cancer patients have higher levels of cmIL-10, it’s possible that the test might be useful for determining whether some patients might benefit from anti-viral drug treatments. If levels are higher in patients with more advanced breast cancer, then it’s possible that screening for cmIL-10 could help doctors monitor whether metastases are more likely to develop or whether a woman’s cancer is responding to treatment.

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Project Title Project Connect Online

Researcher Patricia Ganz, M.D., University of California, Los Angeles.

Study Summary The purpose of this study is to evaluate the effectiveness of creating a personal website to communicate with others during the experience of metastatic breast cancer.

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Project Title Mapping the Breast Ducts Study

Researcher Susan Love, MD, Dr. Susan Love Research Foundation, Encino, CA

Study Summary The purpose of this research study is to create a functional map of the breast ducts so that doctors can better diagnose, treat, and – eventually – learn how to prevent breast cancer. The research team will first determine the ideal state of the lactating breast for imaging, i.e. full, empty, or in between, as well as the best procedure for capturing the data. The second step will involve recruiting 250 women who are breast feeding to take part in this low risk investigation and undergo whole breast Automated Whole Breast Ultrasound. The research team is currently recruiting 50 women to participate in the first step of this study.

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Project Title Enhancing the Experience of Endocrine Therapy

Researcher Annette Stanton, Ph.D., University of California, Los Angeles, Los Angeles, California

Study Summary In an effort to find the best ways to help women take their endocrine therapy as prescribed, researchers have developed seven brief videos. As a first step in testing the utility of the videos, they have developed questions to get women’s reactions to them. You don’t have to leave your house to participate! Five hundred women are needed for this study. The research team is interested in the experiences of ALL women, including those women who do or do not regularly take their medication.

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