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Project Title Discovery of Early Markers of Breast Cancer (Phase 1)

Researcher Isabelle Bedrosian, MD, and Abenaa Brewster, MD, MD Anderson Cancer Center, Houston, TX

Study Summary A research team at M.D. Anderson Cancer Center is investigating whether the amount of DNA damage seen in the cells in normal breast tissue may be an indicator of future breast cancer risk. The researchers are recruiting women who had a benign breast biopsy and then went on to develop breast cancer AND women who had a benign breast biopsy but did NOT go on to develop breast cancer. By recruiting women who did develop breast cancer and women who did not, they will be able to look for markers in the breast cells that might be an indicator of breast cancer risk.

This Call to Action is for women who had a benign breast biopsy and then developed breast cancer one or more years later.

Who Can Participate? You can join the Discovery of Early Markers of Breast Cancer study if you match ALL of these MAIN categories:
• You had a benign breast biopsy after March 2003
• You were diagnosed with breast cancer (NOT including DCIS) ONE OR MORE YEARS AFTER your benign breast biopsy. The benign biopsy and the cancer do NOT need to be in the same breast.
• You are a woman over the age of 18
• You were NOT pregnant or breastfeeding when you had the benign breast biopsy
• You were NOT using birth control pills or menopausal hormone therapy when you had the benign breast biopsy
• You have NOT tested positive for a BRCA 1 or BRCA 2 mutation (if known)
• You live in the United States

After you RSVP, the research team will contact you to ask additional questions to be sure that this study is a right fit for you.

What Does Participation Involve? If you agree to participate in the Discovery of Early Markers of Breast Cancer study, you will be asked to fill out a questionnaire about your reproductive history, smoking history, and family health background. You will receive and then return this questionnaire by mail (at no cost to you). You will then need to ask your doctor or pathologist for two things: the pathology slides from your benign breast biopsy and a block of your paraffin embedded benign breast tissue. (You will be given a detailed instruction sheet to give to your doctor or pathologist to explain what is needed and why.) You will mail these items to the researchers, at no cost to you. If you prefer, you can give the researcher team permission to request the pathology slides and tissue block from your doctor.

The researchers may contact you at a later date to see if you would be willing to have a core biopsy so that they can obtain additional tissue for their study. The core biopsy would be performed on the opposite, unaffected breast. The research team will assist you in getting to a clinic where the core biopsy can be performed, and will provide you with information about how the tissue sample can be mailed to the researchers, at no cost to you.

Finally, the researchers may contact you at a later date to ask you to request a block of your paraffin embedded tumor tissue from your doctor or pathologist. (You will be given a detailed instruction sheet to give to your doctor or pathologist to explain what is needed and why). You will mail this item to the researchers, at no cost to you.

The researchers need to enroll 150 women in this study.

Where? Anywhere in the US