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Project Title Interpersonal Therapy for Depression in Breast Cancer Study

Researcher Carlos Blanco, MD, PhD, New York State Psychiatric Institute/Columbia University, New York, NY

Study Summary The purpose of this study is to see which type of talk therapy is the most effective treatment for depression in women and men who have had a breast cancer diagnosis. It is open to women and men who were diagnosed with stage I-IV breast cancer more than six months ago.

Who Can Participate? You can join the Interpersonal Therapy for Depression in Breast Cancer Study if you match ALL of these MAIN categories:

• You are a woman or man, 18 years of age or older
• You have been diagnosed with Stage I, II, III, or IV breast cancer
• You were diagnosed with breast cancer more than 6 months ago
• You are able to speak English OR Spanish
• You have been feeling down, sad, or depressed
• You do not have a history of psychosis or bipolar disorder
• You live near or are willing to travel (at your own expense) to the New York State Psychiatric Institute in New York, NY

Please note that these are only the MAIN eligibility criteria and you will need to participate in a preliminary screening with the research team to determine if you are eligible for study. After you RSVP, the research staff will contact you to ask additional questions to be sure that this study is the right fit for you.

What Does Participation Involve? If you sign up for the Interpersonal Therapy for Depression in Breast Cancer Study, you will be contacted by the research team to answer questions about your breast cancer diagnosis, medical history, and depression. If you appear to be eligible, you will be asked to go to the New York State Psychiatric Institute for screening and evaluations to verify your eligibility for the study. If you are eligible, and you decide to join the study, you will be assigned randomly (like flipping a coin) to one of three talk therapy treatments: Interpersonal Psychotherapy, Problem-Solving Therapy, or Brief Supportive Psychotherapy. All sessions are provided at no cost to you.

Study procedures:
• Participate in twelve 50-minute one-on-one sessions with a study therapist over 16 weeks.
• Meet with an independent evaluator–someone other than your therapist who will evaluate your progress–once a month during the study.
• Meet with an independent evaluator—someone other than your therapist—who will ask you questions about your mood and your daily functioning. These meetings will take place before you begin treatment, 4 and 8 weeks after you begin treatment, and at the end of treatment.
• Participate in evaluations and assessments 2 and 4 months after the end of treatment.

Where? New York State Psychiatric Institute, New York, New York