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Project Title Discovery of Early Markers of Breast Cancer (Phase 2)

Researcher Isabelle Bedrosian, MD, and Abenaa Brewster, MD, MD Anderson Cancer Center, Houston, TX

Study Summary A research team at M.D. Anderson Cancer Center is investigating whether the amount of DNA damage seen in the cells in normal breast tissue may be an indicator of future breast cancer risk. The researchers are currently recruiting women who had had a benign breast biopsy and then went on to develop breast cancer (Phase 1). NOW, they also need women who had a benign breast biopsy but did NOT go on to develop breast cancer (Phase 2). By recruiting women who did develop breast cancer and women who did not, they will be able to look for markers in the breast cells that might be an indicator of breast cancer risk.

This Call to Action is for women who had a benign breast biopsy but did NOT go on to develop breast cancer.

Who Can Participate? You can join the Discovery of Early Markers of Breast Cancer study if you match ALL of these MAIN categories:

• You are a woman between the ages of 20 - 54
• You have had screening mammograms performed
• You have NOT been diagnosed with breast cancer (including DCIS)
• You had a benign breast biopsy between January 1999 and December 2006
• You were NOT pregnant or breastfeeding when you had the benign breast biopsy
• You were NOT using birth control pills or menopausal hormone therapy when you had the benign breast biopsy
• You have NOT tested positive for a BRCA 1 or BRCA 2 mutation (if known)
• You live in the United States

After you RSVP, the research team will ask you additional questions to be sure that this study is a right fit for you.

What Does Participation Involve? If you agree to participate in the Discovery of Early Markers of Breast Cancer study, you will be asked to fill out a questionnaire about your reproductive history, smoking history, and family health background. You will receive and then return this questionnaire by mail (at no cost to you). You will then need to ask your doctor or pathologist for two things: the pathology slides from your benign breast biopsy and a block of your paraffin embedded benign breast tissue. (You will be given a detailed instruction sheet to give to your doctor or pathologist to explain what is needed and why.) You will mail these items to the researchers, at no cost to you. If you prefer, you can give the researcher team permission to request the pathology slides and tissue block from your doctor.

The researchers need to enroll 400 women in this study.

Where? Anywhere in the US (all participation is handled in the mail)