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The goal of this study is to learn more about breast cancer in Hispanic women by studying Hispanic women with breast cancer and Hispanic women who have never had breast cancer. The research team has enrolled Hispanic women with breast cancer for the study. Now, they need Hispanic women who have never had any type of cancer (skin cancers are okay).
With advances in technology, genomics is becoming increasingly important for personalized medicine, both for determining risk of developing disease and for making treatment-related decisions. In order to better prevent and treat breast cancer, we need to identify individuals who are at high risk due to inherited genetic mutations. In this proposal, we will focus on breast cancer in Hispanic women. Although Hispanics represent the fastest growing ethnic population in the U.S., they have been largely understudied in terms of genetic susceptibility to cancer even though breast cancer is the most common cancer and causes the most cancer deaths in Hispanic women. The overall long-term goal of this project is the development of a comprehensive clinical genetic test that provides a set of susceptibility genes for inherited breast cancer and can be readily integrated into clinical practice. Specific Aim 1 is to identify variants in 605 genes involved in DNA damage response pathways using next-generation sequencing. We will use DNA from 1000 Latina breast cancer patients and 1000 healthy Latina controls. Specific Aim 2 is to identify the set of variants of biological significance through in silico analyses. Specific Aim 3 is to perform gene-based association tests of the genes and risk to develop breast cancer.