Obesity is a complex phenotype resulting from interactions between genetics, diet, hormones, physical activity and environmental factors. Adulthood weight gain and obesity raises breast cancer risk after menopause and increases the likelihood of an adverse prognosis among women already diagnosed with breast cancer. The purpose of this research is to pilot test interventions that are linked to a lowered risk of recurrence and mortality among women already diagnosed with breast cancer and a lower risk of developing breast cancer among postmenopausal women. To better understand the conduct of these interventions, we propose a 12-week pilot intervention study to investigate whether interventions that contain both dietary and exercise components designed to reduce body weight affect body composition, hormones and biomarkers in apparently healthy postmenopausal women. We plan to use the findings from the pilot study to assist with funding application, design and implementation of a dietary and exercise intervention in postmenopausal breast cancer survivors and postmenopausal high-risk women.
This study at the University of California, Los Angeles, is investigating whether exercise and dietary interventions designed to reduce body weight affect body composition, hormones, and biomarkers in healthy postmenopausal women. The researchers were looking to enroll at least 20 volunteers. The Call to Action for this study was sent to Army of Women members on January 7, 2009. The researchers were able to close enrollment just two days later on January 9, 2009, after the Army of Women provided them with 125 women who were interested in enrolling in the study.