The research hypothesis of this proposal is that there are distinct pathologic and clinical characteristics in women with breast cancer that significantly increases their risk for subsequent uterine cancer. By identifying these modifiable characteristics we can improve clinical care, thus improving the health of these women by allowing them to avoid the unnecessary morbidity and potential mortality of subsequent uterine cancer. Using a case-control study design we will administer surveys aiming to predict which patients are at risk for developing uterine cancer, potentially improving survival for these breast cancer patients. To realize this goal the current study has the following specific aims:
First Objective: Determine the specific pathologic and clinical characteristics that significantly increases the odds a woman with breast cancer subsequently develop uterine cancer.
Second Objective: Test the feasibility and acceptability of tests predicting risk of uterine cancer in women with breast cancer
The purpose of this study at the University of Louisville Brown Cancer Center, in Kentucky, is to develop a tool that can determine whether a woman who has had breast cancer is at high risk of developing uterine cancer. The research team used an online survey to identify factors that are associated with developing uterine cancer after breast cancer. The researchers wanted to enroll up to 10,000 volunteers. The Call to Action for this study was sent to Army of Women members on February 9, 2012. The researchers were able to close enrollment on August 31, 2012, after the Army of Women provided them with 7,660 women who were interested in enrolling in the study.