This project is based on the hypothesis that the genetic abnormalities in normal-appearing breast epithelium of breast cancer patients are cancer specific, biologically meaningful and clinically relevant. In four specific aims the research team will discover the DNA copy number variation (CNV), mRNA, and miRNA landscape of a series of paired and/or matched tissues. The results should illuminate the molecular pathogenesis of breast cancer at its earliest stages, discover novel markers of breast cancer risk or susceptibility, and identify new candidate treatment and prevention targets.
Researchers at Boston Medical Center are studying breast cells from biopsies of normal breast tissue, atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS) to learn more about breast cancer progression. Their goal is to identify similarities and differences seen in biological markers (molecular characteristics or substances) in these different types of tissue. They used a variety of recruitment methods, including the Army of Women (AOW), to enroll up to 40 volunteers. The Call to Action for this study was sent to AOW members on July 10, 2013, and the researchers closed enrollment on April 4, 2014. The AOW provided them with three women who were interested in enrolling in the study.