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Cognition in Older Breast Cancer Survivors: Treatment Exposure, APOE and Smoking History Study

Tim Ahles, PhD, and Elizabeth Ryan, PhD, Memorial Sloan-Kettering Cancer Center, New York, Arti Hurria, MD, City of Hope Medical Center, Duarte, CA
Study abstract

The objective of this study is to unite the fields of geriatrics, neuropsychology, oncology, and genetics to study the prevalence and trajectory of cognitive impairment in a cohort of older, long-term (5-15 years) breast cancer survivors. The research team will examine the interactions of therapeutic exposures, genetic polymorphisms, and smoking history in predicting differences in cognitive performance between breast cancer survivors and controls at enrollment, controlling for burden of comorbidity and frailty (an overall measure of health status which has been shown to be a predictor of morbidity and mortality in adults age 65 and older.

Study review

The purpose of this study was to evaluate how cancer treatments, genetics, and smoking history affect thinking and memory in older women. The researchers wanted to enroll up to 480 volunteers from the Army of Women (AOW) from New York, NY or Duarte, CA. The Call to Action for this study was sent to AOW members on October 26th, 2016. The researchers closed enrollment on February 1st, 2018, after the AOW provided them with 161 women who were interested in enrolling in the study.