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Closed Projects

Since October 2008, we have supported more than 120 studies, connecting over 102,000 volunteers with innovative research around the world. These research projects have studied everything from our microbiota to novel breast cancer genes. We have made a point to partner with researchers who are asking important questions that may help eradicate breast cancer.

While these research studies are always different, there is one common factor: our dedicated Army of Women members. With their help, the following supported studies completed enrollment:

In an effort to find the best way to help medical personnel and women diagnosed with breast cancer, researchers at the University of California, Los Angeles, have developed an online survey to understand women’s thoughts, feelings, and behaviors relevant to taking endocrine therapies. The researchers wanted to enroll at least 500 volunteers. The Call to Action for this study was sent to Army of Women members on January 11, 2012. The researchers were able to close enrollment on January 23, 2012, after the Army of Women provided them with 2,483 women who were interested in enrolling in the study.

Date closed: January 23, 2012

This study at Yale University, in New Haven, Conn., is examining the DNA of women who have had ductal carcinoma in situ (DCIS) and have the BRCA1 or BRCA2 mutation. The researchers wanted to enroll 200 volunteers. The Call to Action for this study was sent to Army of Women members on January 6, 2010. The researchers were able to close enrollment on January 20, 2012, after the Army of Women had provided them with 200 women who were interested in enrolling in the study.

Date closed: January 20, 2012

This study will collect the PGE-M and COX-2 IHC levels in subjects with breast cancer to establish whether urinary PGE-M can be used as a surrogate marker for increased COX-2 expression.

AIMS:
1. The primary objective is to determine the level of PGE-M in the urine of breast cancer patients.
2. The secondary objective is to correlate PGE-M expression in urine expression of COX-2 through IHC in tumor tissue.
3. The third objective is to test the difference in urinary PGE-M level between the patients with tumor and patients without tumor.

To pursue above mentioned hypothesis and aims, we plan to study female patients ≥18 years of age with either metastatic or early stage breast cancer with intact tumor and patients who have been recently diagnosed with breast cancer and are currently tumor-free.

One urine sample and one tumor sample from tumor paraffin blocks (5 slides minimum) will be taken from approximately 340 breast cancer patients according to the following scheme:
80 Her2/neu positive by IHC or FISH positive (any ER/PR) patients
80 ER+ and/or PR+ patients/Her2/neu negative by IHC or FISH negative
80 triple negative patients (Her2/neu negative by IHC or FISH negative, ER-, PR)
100 recently diagnosed patients who have had surgical resection and have no tumor present to serve as negative controls, no specific Her2/neu or ER/PR receptor status is required from this group of patients.

Date closed: January 16, 2012

The research team is studying how well yoga, exercise, and omega-3 fatty acids (fish oil) work to ease hot flashes and night sweats. A total of 375 women will be participating in this study across the United States at three research sites: Indiana University School of Nursing, in Indianapolis, Kaiser Permanente Northern California, in Oakland, Calif., and Group Health Research Institute, in Seattle. The Call to Action for this study was sent to Army of Women members on June 15, 2011. When the researchers closed enrollment on January 5, 2012, the Army of Women had provided them with 145 women who were interested in enrolling in the study.

Resulting Publications:

Date closed: January 5, 2012

This study at Northwestern University, in Chicago, and Johns Hopkins University, in Baltimore, is looking for a better way to predict a woman’s breast cancer risk, and is investigating the potential for using DNA methylation and estrogen concentrations found in women’s breast tissue as risk biomarkers. The researchers wanted to enroll at least 400 volunteers. The Call to Action for this study was sent to Army of Women members on July 22, 2009. When the researchers closed enrollment on November 21, 2011, the Army of Women had provided them with 849 women who were interested in enrolling in the study.

Resulting Publications:

Date closed: November 21, 2011

This study at Loma Linda University, in California, is investigating the effect that a social-networking website that allows cancer patients to communicate, share information, and provide support to others over the Internet has on cancer-related distress. The researchers wanted to enroll at least 120 women and men who had been diagnosed with breast cancer. The Call to Action for this study was sent to Army of Women members on August 24, 2011. The researchers were able to close enrollment on August 25, 2011, after the Army of Women provided them with 380 people who were interested in enrolling in the study

Resulting Publications:

Date closed: August 25, 2011

A research team at Columbia University, in New York City, is conducting two studies: one is investigating the effectiveness of Omega-3 fatty acid; the second is investigating the effectiveness of Glucosamine and Chondroitin. Both studies are assessing whether a dietary supplement can reduce joint pain and stiffness associated with the aromatase inhibitors used to treat breast cancer. The researchers wanted to enroll at least 50 volunteers in each study. The Call to Action for this study was sent to Army of Women members on May 26, 2010. When the researchers closed enrollment on August 19, 2011, the Army of Women had provided them with 85 women who were interested in enrolling in the studies.

Date closed: August 19, 2011

This study at New York University School of Medicine and Albert Einstein College of Medicine, in New York City, is studying DNA from Ashkenazi Jewish women for two reasons: to try to identify new genes that might reduce breast and ovarian cancer risk in women who have a BRCA1 and BRCA2 mutation; and to try to identify genes, other than BRCA 1 and BRCA2, that increase breast and ovarian cancer risk in Ashkenazi Jewish women. The researchers initially wanted to enroll at least 1,000 women of Ashkenazi Jewish descent; they later increased their enrollment goal to a minimum of 2,000 women after the tremendous response from Army of Women members. The Call to Action for this study was sent to Army of Women members on November 10, 2010. When the researchers closed enrollment on June 9, 2011, the Army of Women had provided them with 4,620 women who were interested in enrolling in the study.

Research Webinar:
Jewish Women’s Breast and Ovarian Cancer Genetic Study

Resulting Publications:

Date closed: June 9, 2011

This study at Niagara University, in Lewiston, NY, is analyzing urine samples from women with breast cancer and women who have never been diagnosed with any kind of cancer to look for biomarkers that may be a sign of cancerous breast tissue. The researchers will also compare the biomarkers found in the women’s urine to see if they can identify the stage of breast cancer based on the types and levels of the biomarkers. The researchers wanted to enroll at least 200 women who have never been diagnosed with any kind of cancer and at least 1,000 women with breast cancer. The Call to Action for this study was sent to Army of Women members on June 8, 2011, and closed 8 hours later on June 8, 2011, after the Army of Women provided them with 2,075 women who were interested in enrolling in the study.

Date closed: June 8, 2011

Researchers throughout the country are working with the National Cancer Institute’s Cancer Information Service to determine the best way to get information about treatment options to women who have been recently diagnosed with breast cancer. The researchers want to find the best way to deliver the information: by mail, in the form of print materials, or by the Internet. The researchers wanted to enroll at least 720 volunteers. The Call to Action for this study was sent to Army of Women members on April 7, 2010. When the researchers closed enrollment on June 2, 2011, the Army of Women had provided them with 347 women who were interested in enrolling in the study.

Resulting Publications:

Date closed: June 2, 2011

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